Browse 8 peer-reviewed articles
Background: Early detection of heart failure remains a critical challenge in cardiovascular medicine. This multicenter prospective study evaluated novel circulating biomarkers—including high-sensitivi...
This Phase III randomized controlled trial investigated pembrolizumab combined with standard chemotherapy in 634 patients with early triple-negative breast cancer. The combination therapy demonstrated...
Emerging evidence suggests metabolic pathways play significant roles in neurodegeneration. This retrospective cohort study of 1.2 million individuals assessed whether GLP-1 receptor agonist use was as...
The R21/Matrix-M malaria vaccine demonstrated 74–77% efficacy against clinical malaria in African children aged 5–36 months in a Phase IIb trial across four Sub-Saharan African countries. This study p...
KRAS mutations, present in 95% of pancreatic ductal adenocarcinomas, have historically been considered undruggable. This study demonstrates in vivo CRISPR-Cas9 correction of KRASG12D mutations using l...
This systematic review and meta-analysis of 47 randomized controlled trials (n=8,932) evaluated the effects of various intermittent fasting (IF) protocols on metabolic syndrome components. IF signific...
Emerging evidence links gut-brain axis dysregulation to psychiatric disorders. This 5-year longitudinal cohort study followed 3,400 participants, analyzing gut microbiome composition via 16S rRNA sequ...
This multicenter validation study assessed a deep learning algorithm for pulmonary nodule detection on 18,432 CT scans from 6 academic medical centers. The AI system achieved sensitivity of 94.6% and...