Impact of Intermittent Fasting on Metabolic Syndrome Biomarkers: Systematic Review

Abstract

This systematic review and meta-analysis of 47 randomized controlled trials (n=8,932) evaluated the effects of various intermittent fasting (IF) protocols on metabolic syndrome components. IF significantly reduced fasting glucose (WMD: -8.2 mg/dL), triglycerides (WMD: -22.5 mg/dL), blood pressure, and waist circumference compared to continuous caloric restriction. Time-restricted eating (16:8) showed the strongest adherence rates. IF represents a viable dietary intervention for metabolic syndrome management.

Keywords:

intermittent fasting metabolic syndrome insulin resistance obesity diet