Novel Biomarkers for Early Detection of Heart Failure: A Multicenter Study

Abstract

Background: Early detection of heart failure remains a critical challenge in cardiovascular medicine. This multicenter prospective study evaluated novel circulating biomarkers—including high-sensitivity troponin I, NT-proBNP, and galectin-3—for their predictive value in identifying subclinical heart failure. Methods: We enrolled 2,847 participants across 12 medical centers globally. Results: The combination biomarker panel achieved an AUC of 0.94 (95% CI: 0.91–0.97) for early HF detection, outperforming individual markers. Conclusions: Multi-biomarker panels significantly improve early heart failure detection, enabling timely intervention.

Keywords:

heart failure biomarkers NT-proBNP troponin cardiovascular